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KMID : 0360419940300030291
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Korean Journal of Pharmacology
1994 Volume.30 No. 3 p.291 ~ p.297
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Effects of Neuroleptics on the Opioid Receptor Binding in the Mouse Striatum
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Kim Soo-Kyung
Lee Seung-Ryong
Park Chang-Gyo
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Abstract
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Our purpose was to gain insight into a possible modulatory role for opioid receptors by neuroleptics (chlorpromazine, thioridazine, haloperidol, sulpiride, and pimozide) in chronic morphine 5 mg/kg and 20 mg/kg treated mouse striatum. We attempted quantitative receptor assays using highly specific radioligands, , and to measure the binding affinity in the experimental groups. The decrease of binding was potentiated by sulpiride and pimozide in the chronic morphine treatment (5 mg/kg and 20 mg/kg). The decrease of binding was inhibited by chlorpromazine, thioridazine, haloperidol, sulpiride, and pimozide in chronic morphine treatment (5 mg/kg and 20 mg/kg). The decrease of binding was significantly inhibited by chlorpromazine, thioridazine, sulpiride, and pimozide in chronic morphine 20 mg/kg treatment. binding on the neuroleptics was antagonized by naloxone pretreatment in chronic morphine 20 mg/kg treatment. These findings suggest that neuroleptics influence opposing tonically active on the opioid receptor compared with opioid receptor in the chronic morphine treated mouse striatum.
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KEYWORD
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Opioid binding, Neuroleptics
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